ABSTRACT
In this report, we present a case of a patient with Philadelphia chromosome-positive (Ph+) B-cell acute lymphoblastic leukemia after renal transplantation. The patient, a 65-year-old man, had received a kidney transplantation 20 years prior to diagnosis with Ph+ precursor B-cell ALL. Because he was refractory to intensive chemotherapy and had refused to receive additional intensive chemotherapy, he was treated with imatinib and dexamethasone. While this patient experienced a complete hematologic and cytogenetic response, he did not show a complete molecular remission. Eighty days after imatinib combination therapy, the patient relapsed and died from intracerebral hemorrhage.
Subject(s)
Aged , Humans , B-Lymphocytes , Benzamides , Cerebral Hemorrhage , Cytogenetics , Dexamethasone , Kidney Transplantation , Philadelphia , Philadelphia Chromosome , Piperazines , Precursor Cell Lymphoblastic Leukemia-Lymphoma , Precursor Cells, B-Lymphoid , Pyrimidines , Imatinib MesylateABSTRACT
Burkholderia cepacia is an important pathogen of humans in both immunocompromised or hospitalized patients. This aerobic gram-negative rod causes various clinically significant infections such as pneumonia, bacteremia, urinary tract infection, peritonitis, endophthalmitis, and keratitis. This uncommon pathogen is mainly associated with cystic fibrosis, dialysis, and immunocompromised states. We observed a 73-year-old woman without any underlying diseases, who had both lower leg pain and fever. She was later found to have spondylitis with epidural abscess at L5-S1. Culture of the epidural abscess revealed the growth of B. cepacia. To the best of our knowledge, this is the first case of pyogenic spondylitis caused by a rare infection of B. cepacia to be reported in Korea
Subject(s)
Adult , Aged , Female , Humans , Bacteremia , Burkholderia , Burkholderia cepacia , Cystic Fibrosis , Dialysis , Endophthalmitis , Epidural Abscess , Fever , Keratitis , Korea , Leg , Peritonitis , Pneumonia , Spondylitis , Urinary Tract InfectionsABSTRACT
Burkholderia cepacia is an important pathogen of humans in both immunocompromised or hospitalized patients. This aerobic gram-negative rod causes various clinically significant infections such as pneumonia, bacteremia, urinary tract infection, peritonitis, endophthalmitis, and keratitis. This uncommon pathogen is mainly associated with cystic fibrosis, dialysis, and immunocompromised states. We observed a 73-year-old woman without any underlying diseases, who had both lower leg pain and fever. She was later found to have spondylitis with epidural abscess at L5-S1. Culture of the epidural abscess revealed the growth of B. cepacia. To the best of our knowledge, this is the first case of pyogenic spondylitis caused by a rare infection of B. cepacia to be reported in Korea
Subject(s)
Adult , Aged , Female , Humans , Bacteremia , Burkholderia , Burkholderia cepacia , Cystic Fibrosis , Dialysis , Endophthalmitis , Epidural Abscess , Fever , Keratitis , Korea , Leg , Peritonitis , Pneumonia , Spondylitis , Urinary Tract InfectionsABSTRACT
Rituximab is a human/murine chimeric anti-CD20 mono- clonal antibody used to treat CD20-positive B-cell non- Hodgkin's lymphoma (NHL). Although most of the adverse effects associated with rituximab are usually reversible and temporary infusion-related reactions, including fever, chills, flushing and skin reactions, there are several reports of pulmonary events after long-term administration of rituximab. We present a case of asymp-tomatic nodular organizing pneumonia occurring during rituximab-based chemotherapy in a patient with non- Hodgkin's lymphoma.
Subject(s)
Humans , B-Lymphocytes , Chills , Drug Therapy , Fever , Flushing , Hodgkin Disease , Lymphoma, Non-Hodgkin , Pneumonia , Skin , RituximabABSTRACT
Malignant insulinomas are very rare endocrine tumours with a variable clinical course. Here, a case of a malignant insulinoma, resected from the tail of the pancreas 10 years previously, which was found to have hepatic metastasis, is reported. A pancreatic mass, without evidence of metastasis, has been found using an abdominal CT scan and intra-operative ultrasonography 10 years previously. Recently, the patient has suffered from dizziness, sweating and an altered mentality. Hyperinsulinemia was diagnosed from the biochemical laboratory finding. An abdominal CT scan and intra-operative abdominal sonography showed multiple hepatic metastasis, without local recurrence in pancreas. Therefore, a partial hepatic segmentectomy was performed. Immunohistochemical staining of the postoperative specimen was strongly positive for insulin. The postoperative biochemical response was normalized, and the patient experienced no further hypoglycemic symptom.